A new study points out that the duration of sleep can influence the effectiveness of vaccination. According to a meta-analysis published in the scientific journal Current Biology, sleeping less than six hours per night around the time of vaccination can significantly decrease the antibody response of the body.
The research, which included data on influenza and hepatitis vaccines, suggests that interventions simple behaviors, such as getting enough sleep, may be important in improving response to vaccination against COVID-19.
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The researchers highlighted that the weakened antibody response in individuals with shortened sleep was so intense that resembled the observed decline in COVID-19 antibodies two months after vaccination with Pfizer-BioNTech or Modern.
Although there is still no comparable data on vaccination against COVID-19, the meta-analysis suggests that getting enough sleep before and after inoculation may be important for vaccine efficacy.
The researchers also investigated the data by sex and found a robust association between sleep duration and antibody response in men. More data are needed to determine the influence of sleep on the vaccination response in women, as the studies have not controlled for variations in levels of sex hormones, which are known to affect function immunological.
The researchers emphasize the importance of large-scale studies to determine optimal sleep time to promote an optimal vaccine response at the time of inoculation. They also underscore the need to identify simple behavioral interventions that might improve the response to COVID-19 vaccination amid the ongoing pandemic.
