Russian scientists from Belgorod State University, in collaboration with international researchers, have made a revolutionary discovery.
According to the research, a link was identified between a gene that encodes heat shock proteins and the severity of ischemic stroke.
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Ischemic stroke, a devastating cerebrovascular condition, is the leading cause of death globally, according to the World Health Organization.
Both external factors and the genetic predisposition of patients can contribute to the occurrence of this pathological condition.
According to Russian research, in times of stress, including during a stroke, heat shock proteins kick in to minimize damage to brain cells. They play a crucial role in recovering proteins from brain tissue, preventing harmful clumps.
More details of the discovery
Russian scientists, in collaboration with British colleagues, have established a direct connection between the genetic sequence responsible for the HSP70 protein and the consequences of ischemic stroke.
This will allow for a more accurate prediction of the course of the disease and the adaptation of treatment based on the patient's genetic profile.
Although the genetic sequence is usually identical, polymorphism, which involves differences in one or more bases in the sequence, can be observed in a large number of people.
These variations are called alleles and are crucial for identifying stroke risk and disease severity, especially in specific subgroups such as men or smokers.
The director of the Joint Center for Genetic Technologies at Belgorod State University, Aleksei Deikin, emphasized the practical importance of this research.
He mentioned that based on the type of heat shock protein present, appropriate treatment can be selected immediately even in the absence of visible symptoms.
Important revelations
Furthermore, this fundamental study brings us closer to understanding the relationship between genotype and phenotype, representing a significant advance in personalized medicine.
With more than 2,000 participants, this search offers promising perspectives for the diagnosis and treatment of patients with ischemic stroke, improving their chances of recovery.
The result found by Russian researchers during the study provides a pattern to be observed that could help identify the disease and how to treat it in the best way, preventing greater risks and helping patients in the correct treatment for each case in particular. specific.
