Research indicates that the incorrect processing of RNA is capable of providing an increase in the Life expectancy of humans.
RNA is a significanttransporter in data in our cells It is it suits as a mold for the production in proteins. When the newly formed RNA raisinby this processing, the introns are withdrawn for to producemRNAsmature what encodeproteins. This cutting is known as “splicing” and its control is maintained by a complex known as “spliceosome”.
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Research done with larvae and their results
“We found a gene in worms, called PUF60, which is involved in RNA splicing and regulates the lifespan”, states doctor Wenming Huang, Max Planck's scientist, who managed to make this discovery.
The mutationsin that gene takeThe splicing withoutprecision and in the retention of introns within some RNAs. As consequence, any less from theproteincorrespondinghe wasactivated from of this RNA. Surprisingly, with the mutation of the PUF60 gene got itsurvivenotablymore than the larvaenormal.
SomeproteinswhatperformA paperon trackinsignalingmTORsufferedespeciallyeffectscausedperthatproductiondefective. That via signaling is a sensor significant to the accessibility in food It is exercisesOpaper in central controlof metabolism cell phone and tinbeenOmainobject for the searchabout aging as goal of potentials medicines anti aging.
You scientists were also capable in to present in cultures in cellsof human beings what degrees reduced from activity of PUF60 resultedatdecreaseof the activityof the way mTOR signaling.
PUF60 mutation in humans
“We believe that by changing Odestiny of introns usRNAs, we have discovered a new mechanism that regulates mTOR signaling and longevity,” said Adam Antebi, director of Max Planck, lead research. “Interestingly, there are also human patients with similar mutations in the PUF60 gene. These patients have defects of growth and riots of neurodevelopment.Perhaps in the future, these patients can be helped for theadministration of medications that control Theactivity from mTOR. But of course this needs more research”, concludes Antebi.
It issearch he was financed by the Max Planck Society.
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