Biochemist and main British scientist at the ICRF, one of the Nobel Prize laureates for Medicine (2001) together with his British colleague Paul Nurse and the American Lee Hartwell, by the discovery of cyclins, the proteins that regulate the action of CDKs, and their degradation at the time of cell division, a mechanism that is essential for the regulation of the cycle. cell. B.A. from the University of Cambridge (1964) and Ph.D. from the University of Cambridge (1965-1968), developed postdoctoral studies at Albert Einstein College of Medicine, New York, and at the Department of Biochemistry, University of Cambridge.
She joined the Imperial Cancer Research Fund (1990), becoming principal scientist at ICRF's Clare Hall Laboratories (1991). In her research, she discovered that cyclins are periodically degraded in the cell cycle, in an important process for controlling this cycle. She discovered the first cyclin in the early 1980s and named them so because the levels of these proteins vary periodically throughout the cycle.
The discovery of cyclin, made in sea urchins of the genus Arbacia, was a result of his discovery that these proteins are periodically degraded during the cell cycle. This degradation is an important cycle control mechanism.
He later discovered cyclins in other species. Today, about ten different cyclins have been found in humans. With several articles published about his researches, he already has many honors and awards such as Fellow of the Royal Society (1991), Foreign Associate of the US National Academy of Sciences (1991) and the Abraham White Scientific Achievement Award of the George Washington University (1993).
Photo copied from the NOBEL e-MUSEUM website:
Order R - Biography - Brazil School