With each passing day, stress, unfortunately, has been more present in people's lives. However, studies reveal that the chronic stress it can cause problems like depression, lack of pleasure and even PTSD. Scientists say that a group of neurons in the shape of an arch becomes hyperactive after chronic exposure to stress. Find out more details on this subject below.
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Scientists at the Medical College of Georgia at Augusta University observed in the hypothalamus, a population of neurons called proopiomelanocortin, or POMC, to responses to ten days of stress chronic.
They then found that stress increased the spontaneous firing of these neurons POMC in male and female mice, says lead author Xin-Yun Lu.
When there was activation of neurons, in addition to directly affecting stress, there were also observations regarding the inability to feel pleasure and the development of depression.
When it comes to humans, the effects can cause problems interacting with friends and loss of libido. In mice, however, there is a loss of the pleasure of sugar water and males are no longer interested in the smell of female urine when they are in heat.
In contrast, when the scientists inhibited the neurons, there was a drastic reduction in behavioral changes. Therefore, the results indicate that POMC neurons are indeed capable of increasing susceptibility to stress.
Both POMC neurons and AgRP neurons are located in the nucleus of the hypothalamus. While the former stimulates stress, the latter plays an important role in resilience to chronic stress and depression. Through these studies, it was concluded that as AgRP activation increases, POMC activation decreases.
They also discovered that chronic stress disrupts the yin-yang balance between these two neuronal populations. Even though AgRP is extremely important for the firing activities of POMC neurons, the mechanism Intrinsic stress is probably the main mechanism underlying the hyperactivity of POMC neurons under stress. chronic.